Δεναξά Μυρτώ
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Ioannis Charalampopoulos, PhD Assistant Professor School of Medicine / Department of Pharmacology University of Crete Affiliated Researcher, Institute of Molecular Biology & Biotechnology - FORTH Email: Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. / Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. Tel: 2810394531 Lab web page: http://regenera-pharm.med.uoc.gr / http://www.imbb.forth.gr/en/research-en/neurosciences/item/3677-ioannis-charalampopoulos |
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Education
Research Interests We are focusing our research interests on the investigation of the molecular mechanisms that neurotrophic factors and their receptors are using to regulate the regenerative capacity of the adult nervous system. Neurotrophins, control brain development and maintenance during adulthood and in aging, while they importantly participate in neuronal survival, differentiation and repair. Our studies are ranging from neurotrophin receptors’ signaling to adult hippocampal neurogenesis to development of novel ligands with specific effects on these receptors (mainly the Trks and p75NTR receptors) and their therapeutic potential on animal models of neurodegenerative diseases (Alzheimer’s Disease). Funding European Commission, Marie Sklodowska Curie Actions - Innovative Training Networks (ITN). Call: H2020-MSCA-ITN-2017, National Funding: Call for Operational Programme 'Competitiveness, Entrepreneurship and Innovation’ (GSRT). Grants from Niarchos and Bodossakis Foundations Selected Publications Pediaditakis I, Kourgiantaki A, Prousis KC, Potamitis C, Xanthopoulos KP, Zervou M, Calogeropoulou T, # Charalampopoulos I, Gravanis A. Front Pharmacol . 2016. 7:512. Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, #Charalampopoulos I, Gravanis A. Neuropharmacology . 2016. 111:266-282. Efstathopoulos P, Kourgiantaki A, Karali K, Sidiropoulou K, Margioris AN, Gravanis A, #Charalampopoulos I.Transl Psychiatry . 2015. 5:e685 Vilar M*, Charalampopoulos I*,Kenchappa RS*, Simi A*, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman W, SchiavoG, BastiaensP, VerveerP, CarterBD, IbáñezCF. Neuron, 2009, 62(1): 72-83 (* equal contributors) |
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Panos Bitsios, MD/PhD
University of Crete Email: Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. Tel: +30 2810 394610 Lab web page: http://bitsioslab.med.uoc.gr |
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Education 1985 BS in Medicine, Aristotle University of Thessaloniki 1993 Certificate of Completion of Psychiatric Training 1997 PhD in Psychopharmacology, University of Nottingham 97-99 Postdoctoral Fellow, University of Nottingham Research Interests Translational research in psychiatry with a focus on developing and exploring valid translational paradigms in humans for research in the psychoses, affective processing in mood disorders, anxiety and arousal. We study (endo)phenotypes such as the prepulse inhibition of the acoustic startle response, aspects of cognition and the modulation of startle and the pupillary light reflexes by affective states, threat, and arousal. We investigate the genetic architecture of these phenotypes, their association with cognitive functions, personality dimensions and their response to pharmacological and psychological interventions in healthy subjects, high risk populations and patients. The central aim is to characterize these phenotypes, in the belief that learning about them will inform us on core pathophysiological dimensions and the neurobiology of psychosis and anxiety. We hope that this will aid psychiatric diagnosis, facilitate the development of customized treatments and ultimately improve patient care. A large part of this work is focused on the neurobiology and genetics of schizophrenia-spectrum disorders.
Funding Onassis Institute and other private benefactors, General Secretariat of Research and Technology – GSRT, Leonardo EU, Janssen-Cilag
Recent Publications or Selected Publications
Roussos P, Giakoumaki SG, Rogdaki M, Pavlakis S, Frangou S, Bitsios P (2008). Prepulse inhibition of the startle reflex in healthy males depends on the catechol O-methyltransferase Val158Met gene polymorphism. Psychological Medicine 38(11):1651-8. Roussos P, Giakoumaki SG, Bitsios P (2009). Tolcapone effects on gating, working memory and mood interact with the synonymous COMT rs4818C/G polymorphism.Biol Psychiatry 66(11):997-1004. Giakoumaki SG, Bitsios P, Frangou S, Roussos P, Aasen I, Galea A, Kumari V (2010).Low Baseline Startle and Deficient Affective Startle Modulation in Remitted Bipolar Disorder Patients and their Unaffected Siblings. Psychophysiology 47: 659-668. Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, Derosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) (2014). Mol Psychiatry. 19(2):168-74. Panos Roussos, Stella G Giakoumaki, Chrysoula Zouraki, John F Fullard, Vasiliki Eirini Karagiorga, Eva-Maria Tsapakis, Zoe Petraki, Larry J Siever, Todd Lencz, Anil Malhotra, Cleanthe Spanaki, Panos Bitsios. (2016). The Relationship of Common Risk Variants and Polygenic Risk for Schizophrenia to Sensorimotor Gating. Biological Psychiatry79(12):988-96. |
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Domna Karagogeos, PhD Professor of Molecular Biology-Developmental Neurobiology Department of Basic Sciences – University of Crete Medical School Affiliated member, Institute of Molecular Biology and Biotechnology - FORTH email: Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. Tel: 2810-394542 Lab web page: http://www.imbb.forth.gr/imbb-people/en/research-karagogeos |
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Education Research Interests
Funding ARISTEIA, ARSEP, SANTE, ELIDEK
Recent Publications Tivodar S., Kalemaki K., Kounoupa Z., Vidaki M., Theodorakis K., Denaxa M., Kessaris N., DeCurtis I., Pachnis V. and Karagogeos D.(2015) Rac-GTPases regulate microtubule stability and axon growth of cortical GABAergic interneurons Cerebral Cortex25(9):2370-82 Bastakis GG, Savvaki M, Stamatakis A, Vidaki M, Karagogeos D. (2015) Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells Development 142(24): 4318-28. Bonetto G, Charalampopoulos I, Gravanis A, Karagogeos D. (2017) The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone-induced death, through the NGF receptor TrkA Glia 65(8):1376-1394. Zoupi L, Savvaki M, Kalemaki K, Kalafatakis I, Sidiropoulou K, Karagogeos D. (2017) The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology Glia66(3):576-591. doi: 10.1002/glia.23266. |
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Maria Venihaki, PhD Associate Professor School of Medicine / Department of Laboratory Medicine University of Crete Email: Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε. Tel: 2810394583 Lab web page: http://clinchem.med.uoc.gr/venihaki.html |
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Education 1991 BS in Pharmacy 1996 PhD in Clinical Chemistry 1999 Postdoctoral Fellow-Children’s Hospital, Harvard Medical School
Research Interests Role of neuropeptides and neurosteroids on physiological and pathophysiological (stress) conditions. Specifically, we study the role of the above molecules: on cutaneous wound healing and skin pathologies; on inflammation and inflammation-induced analgesia; on the molecular mechanisms and the signaling pathways involved in the interaction between neuropeptides/neurosteroids and pain.
Funding Special Account for Research of the University of Crete, H2020 PROGRAM BBI
Selected Publications Rassouli O, Liapakis G, Venihaki M. Role of Central and Peripheral CRH in Skin. Curr Mol Pharmacol. 2018;11(1):72-80. doi: 10.2174/1874467209666161026144219.
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