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Kyriaki (Kiki)Thermos, Ph.D Professor of Pharmacology University of Crete School of Medicine Department of Basic Sciences email: This email address is being protected from spambots. You need JavaScript enabled to view it. Tel: 2810 394533 |
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Education 1976 BS in Chemistry, University of Patras, Patras, Greece 1979 MSc. In Chemistry, New York University, New York, USA 1984 PhD in Chemistry, New York University, New York, USA 1984-86 Postdoctoral Fellow, Training Program in Neuropsychopharmacology
Research Interests The main focus of our studies is to understand the underlying mechanisms involved in ischemia induced retinal diseases (e.g. excitotoxicity, oxidative stress) and to investigate new therapeutic targets. We examine the pharmacology of the endocannabinoid system, neurosteroidal neurotrophins, NADPH Oxidase (NOX1,2,4) inhibitors in the rodent retina with emphasis on their role in neuroprotection, inflammation and angiopathy. The pharmacodynamic and pharmacokinetic (intraperitoneal and eye drop administration) profiles of selective agents from these three pharmacological families are studied using in vivo experimental models of retinopathy. Pertaining specifically to the endocannabioid system, we study the neuroprotective and anti-inflammatory properties of the acute and/or chronic treatment of CB1 receptor agonists/antagonists, CB2 agonists, and inhibitors of endocannabinoid metabolic enzymes. Funding ARISTEIA II, ELIDEK, HORIZON2020
Selected Publications Kokona, D, Spyridakos, D., Tzatzarakis, M., Papadogkonaki, S., Filidou, E, Arvanitidis, K.I, Kolios, G., Lamani, M., Makriyannis, A., Malamas, M., Thermos K. (2021) Neuropharmacology 1;185:108450. doi: 10.1016/j.neuropharm. 2021.108450 Spyridakos, D., Dionysopoulou, S., Papadogkonaki, S., Thermos, K. (2020) Effect of acute and subchronic administration of (R)-WIN55,212-2 induced neuroprotection and anti- inflammatory actions in rat retina: CB1 and CB2 receptor involvement. Neurochemistry International. 142: 104907. doi: 10.1016/j.neuint.2020.104907. Dionysopoulou, S., Wikstrom, P., Walum, E., Thermos, K. (2020) Effect of NADPH Oxidase inhibitors in an experimental retinal model of excitotoxity. Experimental Eye Research 200:108232. doi: 10.1016/j.exer.2020.108232. Papadogkonaki S., Theodorakis K, Thermos K. (2019). Endogenous and synthetic cannabinoids induce the downregulation of cannabinoid CB1 receptor in retina. Experimental Eye Research 185, 107694. Ibán-Arias R., Lisa S., Poulaki S., Mastrodimou N., Charalampopoulos I., Gravanis A., Thermos K. (2019) Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina. Graefe's Archive for Clinical and Experimental Ophthalmology, 257:2429-2436. Ibán-Arias R., Lisa S., Mastrodimou N., Kokona D., Koulakis E., Iordanidou, P., Kouvarakis A., Fothiadaki M ., Papadogkonaki S., Sotiriou A., Katerinopoulos H.E., Gravanis A., Charalampopoulos I.,Thermos K. (2018) Diabetes 67:321-333 Kokona D., Georgiou P-C., Kounenidakis M.,Kiagiadaki F., and Thermos K. (2016) Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease. Neural Plasticity, Special Issue on “Cannabinoids in the Brain: New Vistas on an old dilemma”, doi:10.1155/2016/8373020. |
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