Domna Karagogeos, PhD

Professor of Molecular Biology-Developmental Neurobiology

Department of Basic Sciences –

University of Crete Medical School

Affiliated member, Institute of Molecular Biology and Biotechnology - FORTH

email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Tel: 2810-394542

Lab web page: http://www.imbb.forth.gr/imbb-people/en/research-karagogeos

Education

1978       BS in Biology/Chemistry with honors, Simmons College, Boston, USA
1980       MA in Cell and Developmental Biology, Harvard University, Cambridge, USA
1986       PhD in Cell and Developmental Biology, Harvard University, Cambridge, USA
1986-90  Postdoctoral Fellow, Columbia Univ. Medical School and Howard Hughes Medical Inst., Center  for Neurobiology & Behavior (T.M. Jessell lab)

Research Interests

Axoglial interactions during myelination: Our work focuses on a) elucidating axoglial interactions in the juxtaparanodal regions of myelinated fibers in health and demyelinating pathologies b) utilizing models of demyelination/remyelination in vivo and in vitro to test molecules that may influence these processes c) investigating the role of autophagy in CNS myelin homeostasis.
Neuronal migration and cortical interneuron development and function: Cortical Interneurons control the balance of excitation and inhibition and are implicated in  neurodevelopmental pathologies (epilepsy, autism, schizophrenia, bipolar disorder). We are studying the molecular, cellular and functional changes of cortical interneurons in two mouse models of decreased inhibition that we have generated due to the ablation of the small RhoGTPases Rac1 and 3.

Funding 

ARISTEIA, ARSEP, SANTE, ELIDEK

Recent Publications

Tivodar S., Kalemaki K., Kounoupa Z., Vidaki M., Theodorakis K., Denaxa M., Kessaris N., DeCurtis I., Pachnis V. and Karagogeos D.(2015) Rac-GTPases regulate microtubule stability and axon growth of cortical GABAergic interneurons Cerebral Cortex25(9):2370-82

Bastakis GG, Savvaki M, Stamatakis A, Vidaki M, Karagogeos D. (2015) Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells Development 142(24): 4318-28. 

Bonetto G, Charalampopoulos I, Gravanis A, Karagogeos D. (2017) The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone-induced death, through the NGF receptor TrkA Glia 65(8):1376-1394.

Zoupi L, Savvaki M, Kalemaki K, Kalafatakis I, Sidiropoulou K, Karagogeos D. (2017) The function of contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology Glia66(3):576-591. doi: 10.1002/glia.23266.

Kalemaki, K., Konstantoudaki, X., Tivodar, S., Sidiropoulou, K., and Karagogeos, D. (2018) Mice with decreased number of interneuron sex hibitaberrant spontaneous and oscillatory activity in the cortex Front Neural Circuits. 12:96.